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KMID : 0380620220540020155
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 2 p.155 ~ p.162
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Immunostimulatory effects of enzymatic porcine placental hydrolyzate against cyclophosphamide-induced immunosuppressed model
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Kim Keun-Nam
Kim Min-Ju
Yoon Sun-Myung
Kwon Min-Joo
Shin Dong-Yeop
Lee Hak-Yong
Park Young-Mi
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Abstract
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This study investigated the immunostimulatory effect of enzymatic porcine placental hydrolyzate (EPPH) in cyclophosphamide (Cy)-treated rats. This effect of EPPH prevented Cy-induced decreases in body, spleen, and thymus weights and natural killer (NK) cell activity. The numbers of immune cells, such as white blood cells, granulocytes, and lymphocytes, and mid-range absolute counts were significantly higher compared to the control group. The levels of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-2, IL-12, and immunoglobulin G (IgG) were notably reduced by Cy, while EPPH prevented these effects. Histopathological analysis of spleen samples revealed the protective effect of EPPH against Cy-induced immunosuppression. The findings demonstrate that EPPH can alleviate immunosuppression by cell viability, tissue damage, and regulation of the levels of cytokines. EPPH may have value as a component of immunostimulatory agents or an ingredient in functional foods.
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KEYWORD
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enzymatic porcine placenta hydrolysate, immunodeficiency animal model, cyclophosphamide, cytokine, immunostimulation
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